freesurfer-stats/freesurfer_stats/__init__.py

"""
Python Library to Read FreeSurfer's Cortical Parcellation Anatomical Statistics
([lh]h.aparc(.*)?.stats)

Freesurfer
https://surfer.nmr.mgh.harvard.edu/

>>> from freesurfer_stats import CorticalParcellationStats
>>> stats = CorticalParcellationStats.read('tests/subjects/fabian/stats/lh.aparc.DKTatlas.stats')
>>> stats.headers['CreationTime'].isoformat()
'2019-05-09T21:05:54+00:00'
>>> stats.headers['cvs_version']
'Id: mris_anatomical_stats.c,v 1.79 2016/03/14 15:15:34 greve Exp'
>>> stats.headers['cmdline'][:64]
'mris_anatomical_stats -th3 -mgz -cortex ../label/lh.cortex.label'
>>> stats.hemisphere
>>> stats.whole_brain_measurements['estimated_total_intracranial_volume_mm^3']
0    1.670487e+06
Name: estimated_total_intracranial_volume_mm^3, dtype: float64
>>> stats.whole_brain_measurements['white_surface_total_area_mm^2']
0    98553
Name: white_surface_total_area_mm^2, dtype: int64
>>> stats.structural_measurements[['structure_name', 'surface_area_mm^2',
...                                'gray_matter_volume_mm^3']].head()
            structure_name  surface_area_mm^2  gray_matter_volume_mm^3
0  caudalanteriorcingulate               1472                     4258
1      caudalmiddlefrontal               3039                     8239
2                   cuneus               2597                     6722
3               entorhinal                499                     2379
4                 fusiform               3079                     9064


Copyright (C) 2019 Fabian Peter Hammerle <fabian@hammerle.me>

This program is free software: you can redistribute it and/or modify
it under the terms of the GNU General Public License as published by
the Free Software Foundation, either version 3 of the License, or
any later version.

This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
GNU General Public License for more details.

You should have received a copy of the GNU General Public License
along with this program.  If not, see <https://www.gnu.org/licenses/>.
"""

import datetime
import re
import typing

import numpy
import pandas

from freesurfer_stats.version import __version__


class CorticalParcellationStats:

    _HEMISPHERE_PREFIX_TO_SIDE = {'lh': 'left', 'rh': 'right'}
    _GENERAL_MEASUREMENTS_REGEX = re.compile(
        r'^Measure \S+, ([^,\s]+),? ([^,]+), ([\d\.]+), (\S+)$')
    _COLUMN_NAMES_NON_SAFE_REGEX = re.compile(r'\s+')

    def __init__(self):
        self.headers \
            = {}  # type: typing.Dict[str, typing.Union[str, datetime.datetime]]
        self.whole_brain_measurements \
            = {}  # type: typing.Dict[str, typing.Tuple[float, int]]
        self.structural_measurements \
            = {}  # type: typing.Union[pandas.DataFrame, None]

    @property
    def hemisphere(self) -> str:
        return self._HEMISPHERE_PREFIX_TO_SIDE[self.headers['hemi']]

    @staticmethod
    def _read_header_line(stream: typing.TextIO) -> str:
        line = stream.readline()
        assert line.startswith('# ')
        return line[2:].rstrip()

    @classmethod
    def _read_column_header_line(cls, stream: typing.TextIO) -> typing.Tuple[int, str, str]:
        line = cls._read_header_line(stream)
        assert line.startswith('TableCol'), line
        line = line[len('TableCol '):].lstrip()
        index, key, value = line.split(maxsplit=2)
        return int(index), key, value

    def _read_headers(self, stream: typing.TextIO) -> None:
        self.headers = {}
        while True:
            line = self._read_header_line(stream)
            if line.startswith('Measure'):
                break
            if line:
                attr_name, attr_value = line.split(" ", maxsplit=1)
                attr_value = attr_value.lstrip()
                if attr_name in ['cvs_version', 'mrisurf.c-cvs_version']:
                    attr_value = attr_value.strip('$').rstrip()
                if attr_name == 'CreationTime':
                    attr_dt = datetime.datetime.strptime(
                        attr_value, '%Y/%m/%d-%H:%M:%S-%Z')
                    if attr_dt.tzinfo is None:
                        assert attr_value.endswith('-GMT')
                        attr_dt = attr_dt.replace(tzinfo=datetime.timezone.utc)
                    attr_value = attr_dt
                if attr_name == 'AnnotationFileTimeStamp':
                    attr_value = datetime.datetime.strptime(
                        attr_value, '%Y/%m/%d %H:%M:%S')
                self.headers[attr_name] = attr_value

    @classmethod
    def _format_column_name(cls, name: str, unit: typing.Optional[str]) -> str:
        column_name = name.lower()
        if unit not in ["unitless", "NA"]:
            column_name += "_" + unit
        return cls._COLUMN_NAMES_NON_SAFE_REGEX.sub("_", column_name)

    @classmethod
    def _parse_whole_brain_measurements_line(
        cls, line: str,
    ) -> typing.Tuple[str, numpy.ndarray]:
        match = cls._GENERAL_MEASUREMENTS_REGEX.match(line)
        if not match:
            raise ValueError("unexpected line: {!r}".format(line))
        key, name, value, unit = match.groups()
        if (
            key == "SupraTentorialVolNotVent"
            and name.lower() == "supratentorial volume"
        ):
            name += " Without Ventricles"
        column_name = cls._format_column_name(name, unit)
        return column_name, pandas.to_numeric([value], errors="raise")

    @classmethod
    def _read_column_attributes(cls, num: int, stream: typing.TextIO) \
            -> typing.List[typing.Dict[str, str]]:
        columns = []
        for column_index in range(1, int(num) + 1):
            column_attrs = {}
            for _ in range(3):
                column_index_line, key, value \
                    = cls._read_column_header_line(stream)
                assert column_index_line == column_index
                assert key not in column_attrs
                column_attrs[key] = value
            columns.append(column_attrs)
        return columns

    def _read(self, stream: typing.TextIO) -> None:
        assert stream.readline().rstrip() \
            == '# Table of FreeSurfer cortical parcellation anatomical statistics'
        assert stream.readline().rstrip() == '#'
        self._read_headers(stream)
        self.whole_brain_measurements = pandas.DataFrame()
        line = self._read_header_line(stream)
        while not line.startswith("NTableCols"):
            if line.startswith("BrainVolStatsFixed"):
                # https://surfer.nmr.mgh.harvard.edu/fswiki/BrainVolStatsFixed
                assert (
                    line.startswith("BrainVolStatsFixed see ")
                    or line == "BrainVolStatsFixed-NotNeeded because voxelvolume=1mm3"
                )
                self.headers["BrainVolStatsFixed"] = line[len("BrainVolStatsFixed-") :]
            else:
                column_name, value = self._parse_whole_brain_measurements_line(line)
                assert column_name not in self.whole_brain_measurements, column_name
                self.whole_brain_measurements[column_name] = value
            line = self._read_header_line(stream)
        columns = self._read_column_attributes(
            int(line[len('NTableCols '):]), stream)
        assert self._read_header_line(stream) \
            == 'ColHeaders ' + ' '.join(c['ColHeader'] for c in columns)
        self.structural_measurements = pandas.DataFrame(
            (line.rstrip().split() for line in stream),
            columns=[self._format_column_name(c['FieldName'], c['Units']) for c in columns]) \
            .apply(pandas.to_numeric, errors='ignore')

    @classmethod
    def read(cls, path: str) -> 'CorticalParcellationStats':
        stats = cls()
        with open(path, 'r') as stream:
            # pylint: disable=protected-access
            stats._read(stream)
        return stats